The history started during the reign of the British when Sylhet was a part of Assam state. The wife of the cabinet minister of Assam. was treated by Hakim Bashirul Hoque which pleased and highly appreciated by the cabinet Minister. As a reward of this fact the minister gave an institutional shape of Unani Medicine in his state by the request of Hakim Bashirul Hoque. As a result this college was established as Tibbia college , Sylhet in 1945.

The academic activities initially started at Zindabazar in a rented house. Then shifted its Campus at Chalibondor from 1983 to 2012. Thereafter, from 2012 the college continued its activities in the one acre area of land having a green field campus and excellent academic atmosphere at Shahjalal Uposhahar, Sylhet. It has two storied buildings having academic activities and outdoor service. The campus is also enriched with Herbal Gardens. The old campus at Chalibondor has been used as male hostel since 2012 after shifting of academic activities to the new campus. It is to be mentioned that the college was renamed as Government Unani and Ayurvedic Medical college, Sylhet in 2016 and the male hostel as Hakim Bashirul Hoque Chatrabash in 2015.